Dataset de Zenodo · Aird, Steven D.
Data from: Snake venoms are integrated systems, but abundant venom proteins evolve more rapidly
- Licencia
- CC0 1.0uso comercial permitidoTexto de la licencia
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- Formatos
- RMD, GZ
- Tamaño
- 2,2 MB
- Actualizado
- 1 jun 2022
Descripción
Background: While many studies have shown that extracellular proteins evolve rapidly, how selection acts on them remains poorly understood. We used snake venoms to understand the interaction between ecology, expression level, and evolutionary rate in secreted protein systems. Venomous snakes employ well-integrated systems of proteins and organic constituents to immobilize prey. Venoms are generally optimized to subdue preferred prey more effectively than non-prey, and many venom protein families manifest positive selection and rapid gene family diversification. Although previous studies have illuminated how individual venom protein families evolve, how selection acts on venoms as integrated systems, is unknown. Results: Using next-generation transcriptome sequencing and mass spectrometry, we examined microevolution in two pitvipers, allopatrically separated for at least 1.6 million years, and their hybrids. Transcriptomes of parental species had generally similar compositions in regard to protein families, but for a given protein family, the homologs present and concentrations thereof sometimes differed dramatically. For instance, a phospholipase A 2 transcript comprising 73.4 %…
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