Ageing as early-life inertia: disentangling life-history trade-offs along a lifetime of an individual

Описание

The theory that ageing evolves because of competitive resource allocation between the soma and the germline has been challenged by studies showing that somatic maintenance can be improved without impairing reproduction. However, it has been suggested that cost-free improvement in somatic maintenance is possible only under a narrow range of benign conditions. Here we show that experimental downregulation of insulin/IGF-1 signalling (IIS) in C. elegans nematodes, a robustly reproducible lifespan and healthspan-extending treatment, reduces fitness in a complex variable environment when initiated during development but does not reduce fitness when initiated in adulthood. Thus, our results show that the costs and benefits of reduced IIS can be uncoupled when organisms inhabit variable environments, and, therefore, do not provide support for the resource allocation theory. Our findings support the theory that the force of natural selection on gene expression in evolutionarily conserved signalling pathways that shape life-history traits declines after the onset of reproduction resulting in organismal senescence.

Описание из Zenodo, сокращённое.

Файлы (11)

• —_README2,6 кБ
• CSVWideReproduction_A.csv24 кБ
• CSVLifespan_B.csv21 кБ
• CSVLifespan_C.csv23 кБ
• CSVHealthspan.csv400 кБ
• CSVLongReproduction_A.csv94 кБ
• CSVqPCR_data.csv9,3 кБ
• CSVLongReproduction_B.csv81 кБ
• CSVLifespan_A.csv23 кБ
• CSVWideReproduction_B.csv22 кБ
• CSVWideReproduction_C.csv24 кБ

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