Gene Regulatory Network inference in long lived C.elegans reveals modular properties that are predictive of novel ageing genes - Database of Physical gene-gene Interactions in young adult C.elegans.

Description

This repository contains Supplementary Information for manuscript Suriyalaksh et al Gene Regulatory Network inference in long lived C.elegans reveals modular properties that are predictive of novel ageing genes corresponding to the curation of physical gene-gene interactions for young adult C elegans worms We manually curated 239,001 regulatory interactions from 289 young adult wild-type (WT) C.elegans datasets, consisting of 126 genes and 495 unique transcription factors (see TableS1 datasets for prior.csv for references). This repository contains 3 different files: TableS1 datasets for prior.csv - contains datasets used as sources for physical gene-gene or TF-gene interactions TableS2 physical priors.xlsx - contains three tabs: ChIPATAC - contains physical TF-gene interactions from 115 L4 or young-adult ChIP-seq datasets from modERN (Kudron et al., 2018) + ChIP-seq datasets (GSE28350, GSE81521) from (Hochbaum et. al, 2011, Li et. al, 2016). eY1HATAC- contains 3,501 TF-gene interactions from eY1H assay by Fuxman Bass et al. (2016). motifATAC - contains 202 unique TF DNA recognition motifs using “direct evidence” option from CiS-BP motif database (Weirauch et al…

Description from Zenodo, shortened.

Files (3)

• CSVTableS1_datasets_for_prior.csv13 kB
• CSVTableS3_WT_functional_priors.csv1.7 MB
• XLSXTableS2_physical_priors.xlsx3.1 MB

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