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Dataset from Zenodo · Sakyi

AfriDx D6.7 [Dataset v2]: AfriDx Clinical study of NAT in COVID-19

Open on Zenodo
License
CC0 1.0commercial use allowedLicense text
This license allows commercial use. Usually you must credit the author; read the license for the exact terms.
Formats
XLSX, ZIP
Size
36 MB
Updated
Sep 6, 2022

Description

This dataset underlies AfriDx D6.7 report on Clinical study of NAT in COVID-19. Summary of Project The AfriDx Project comprises nucleic acid testing (NAT) for COVID-19 using the PATHPOD system and compared with the RT-qPCR as the gold standard. KNUST, KCCR and NMIMR received PATHPOD and cartridges from the DTU (see D2.2). The cartridges for the testing were shipped in two (2) batches. Training on PATHPOD usage was done and used for testing covid-19 samples. Data obtained was compared with the gold standard RT-PCR. The overall the testing against RT-LAMP was circa 60% sensitive, but the specificity dropped from 80.0% in the first batch to 24% in the second batch. Analysis of the factors causing the drop in specificity is on-going. In the first batch a total of 1,947 tests were conducted, with 531 positive and 1416 negative results, producing 302 samples returning a false positive (FP) 133 samples giving a false negative (FN). The data showed that the FNs could be related to the copy number of virus in the sample, with a strong correlation with RT-PCR C T value and true positive/false negative LAMP outcome. The second batch of nucleic acid testing recorded a total of 1,612 test for…

Description from Zenodo, shortened.

Files (7)

  • XLSXAFRIDx DATA SECOND BATCH.xlsx100 kB
  • ZIPPATHPOD ID 30.zip6.8 MB
  • ZIPPATHPOD ID 25 - BATCH 2.zip2.2 MB
  • ZIPPATHPOD ID 25.zip8 MB
  • ZIPPATHPOD ID26 - BATCH 2.zip2.6 MB
  • XLSXAfridX evaluation data_KNUST.V2.xlsx31 kB
  • ZIPPATHPOD ID26.zip16 MB

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