Dataset from Zenodo · Ivimey-Cook, Edward
Transgenerational fitness effects of lifespan extension by dietary restriction in Caenorhabditis elegans
- License
- CC0 1.0commercial use allowedLicense text
- This license allows commercial use. Usually you must credit the author; read the license for the exact terms.
- Formats
- CSV, TXT
- Size
- 371 kB
- Updated
- Jun 4, 2022
Description
Dietary restriction increases lifespan in a broad variety of organisms and improves health in humans. However, long-term transgenerational consequences of dietary interventions are poorly understood. Here we investigated the effect of dietary restriction by temporary fasting (TF) on mortality risk, age-specific reproduction and fitness across three generations of descendants in C. elegans . We show that while TF robustly reduces mortality risk and improves late-life reproduction of the individuals subject to TF (P 0 ), it has a wide range of both positive and negative effects on their descendants (F 1 -F 3 ). Remarkably, great-grandparental exposure to TF in early-life reduces fitness and increases mortality risk of F 3 descendants to such an extent that TF no longer promotes a lifespan extension. These findings reveal that transgenerational trade-offs accompany the instant benefits of dietary restriction underscoring the need to consider fitness of future generations in pursuit of healthy ageing.
Description from Zenodo, shortened.
Files (6)
DataHunter does not store or host these files: every link leads to the original source. Check the license there before using the data.